期刊
TRENDS IN MOLECULAR MEDICINE
卷 23, 期 8, 页码 675-692出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2017.06.006
关键词
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资金
- FEDER (QREN) through Programa Mais Centro [CENTRO-07-ST24-FEDER-002006]
- Operational Programme Factors Competitiveness-COMPETE 2020
- National Funds through FCT-Foundation for Science and Technology under the Strategic Project [UID/NEU/04539/2013]
- HEALTHYAGING 2020 [CENTRO-01-0145-FEDER-000012]
Obstructive sleep apnea (OSA) is one of the most common sleep disorders. Since aging is a risk factor for OSA development, it is expected that its prevalence will increase with the current increase in life span. In recent years, several studies have shown that OSA potentially contributes to functional decline, mainly prompted by chronic intermittent hypoxia and sleep fragmentation. Here, we propose that OSA might anticipate/aggravate aging by inducing cellular and molecular impairments that characterize the aging process, such as stem cell exhaustion, telomere attrition and epigenetic changes. We suggest that further knowledge on the impact of OSA on aging mechanisms might contribute to a better understanding of how OSA might putatively accelerate aging and aging-related diseases.
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