期刊
TRENDS IN MOLECULAR MEDICINE
卷 23, 期 4, 页码 332-347出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2017.02.004
关键词
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资金
- Canadian Institutes of Health Research (CIHR)
- University of Toronto's Medicine by Design initiative
- Canada First Research Excellence Fund
- Canada Research Chair (CRC) in Comparative Genomics from the CIHR
- CRC in Vascular Cell and Molecular Biology from CIHR
- Ontario Ministry of Research, Innovation and Science
- Canada Graduate Scholarship from the Natural Sciences and Engineering Research Council of Canada
- Youth Abroad Scholarship from the Ministry of Education of Azerbaijan
Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result in myocardial and cerebral infarction. Epigenetic changes are increasingly being associated with atherosclerosis and are of interest from both therapeutic and biomarker perspectives. Emerging genomic approaches that profile DNA methylation, chromatin accessibility, post-translational histone modifications, transcription factor binding, and RNA expression in low or single cell populations are poised to enhance our spatiotemporal understanding of atherogenesis. Here, we review recent therapeutically relevant epigenetic discoveries and emerging technologies that may generate new opportunities for atherosclerosis research.
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