期刊
TRENDS IN MOLECULAR MEDICINE
卷 23, 期 5, 页码 381-392出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2017.02.009
关键词
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资金
- Helen and Robert Ellis Postdoctoral Research Fellowship from the Sydney Medical School Foundation
- Movember Revolutionary Team Award through the Prostate Cancer Foundation Australia
- University of Sydney Australian Postgraduate Award
- National Health and Medical Research Council
- Mostyn Family Foundation
- Guest Family Fellowship
The tumor stroma is a heterogeneous ecosystem comprising matrix, fibroblasts, and immune cells and has an important role in cancer progression. Adipocytes constitute a major component of breast stroma, and significant emerging evidence demonstrates a reciprocal metabolic adaptation between stromal adipocytes and breast cancer (BC) cells. Recent observations promote a model where adipocytes respond to cancer cell-derived endocrine and paracrine signaling to provide metabolic substrates, which in turn drive enhanced cancer cell proliferation, invasion, and treatment resistance. Further defining the mechanisms that underpin this dynamic interaction between stromal adipocytes and BC cells, especially in the context of obesity, may identify novel therapeutic strategies. These will become increasingly important in addressing the clinical challenges presented by obesity and metabolic syndromes.
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