期刊
TRENDS IN MICROBIOLOGY
卷 25, 期 7, 页码 533-546出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2017.01.005
关键词
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资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Stephen I. Morse fellowship
Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance continues to limit therapeutic treatment options. The biological processes used by A. baumannii to cause disease are not well defined, but recent research has indicated that secreted proteins may play a major role. A variety of mechanisms have now been shown to contribute to protein secretion by A. baumannii and other pathogenic species of Acinetobacter, including a type II secretion system (T2SS), a type VI secretion system (T6SS), autotransporter, and outer membrane vesicles (OMVs). In this review, we summarize the current knowledge of secretion systems in Acinetobacter species, and highlight their unique aspects that contribute to the pathogenicity and persistence of these emerging pathogens.
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