期刊
TRENDS IN MICROBIOLOGY
卷 25, 期 9, 页码 768-779出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tim.2017.04.001
关键词
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资金
- State Key Development Programs for Basic Research of China (973 Program) [2015CB554203]
- Key Research and Development Project of China [2016YFA0500600]
- National Natural Science Foundation of China [31270173, 31070114, 81361120383]
- Shanghai Jiao Tong University School of Medicine
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
Protein acetylation is a universal post-translational modification which is found in both eukaryotes and prokaryotes. This process is achieved enzymatically by the protein acetyltransferase Pat, and nonenzymatically by metabolic intermediates (e.g., acetyl phosphate) in bacteria. Protein acetylation plays a role in bacterial chemotaxis, metabolism, DNA replication, and other cellular processes. Recently, accumulating evidence has suggested that protein acetylation might be involved in bacterial virulence because a number of bacterial virulence factors are acetylated. In this review, we summarize the progress in understanding bacterial protein acetylation and discuss how it mediates bacterial virulence.
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