期刊
TRENDS IN IMMUNOLOGY
卷 38, 期 3, 页码 217-228出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.12.003
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资金
- ANRS (France Recherche Nord&Sud Sida - HIV Hepatites)
- Belgian Fund for Scientific Research (FRS-FNRS)
- Fondation Roi Baudouin
- NEAT program (Networking to Enhance the Use of Economics in Animal Health Education, Research, and Policy Making)
- Walloon Region (Fonds de Maturation)
- University of Brussels [Action de Recherche Concertee (ARC) grant]
Combinatory antiretroviral therapy (cART) increases the survival and quality of life of HIV-1-infected patients. However, interruption of therapy almost invariably leads to the re-emergence of detectable viral replication because HIV-1 persists in viral latent reservoirs. Improved understanding of the molecular mechanisms involved in HIV-1 latency has paved the way for innovative strategies that attempt to purge latent virus. In this article we discuss the results of the broadly explored 'shock and kill' strategy, and also highlight the major hurdles facing this approach. Finally, we present recent innovative works suggesting that locking out latent proviruses could be a potential alternative therapeutic strategy.
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