期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1868, 期 2, 页码 510-520出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2017.09.006
关键词
RNA helicase; Translation; DDX3; eIF4A; DDX
资金
- NIH [RO1CA207208]
- Dutch Cancer Foundation [UU2013-5851]
Cancer cells are reliant on the cellular translational machinery for both global elevation of protein synthesis and the translation of specific mRNAs that promote tumor cell survival. Targeting translational control in cancer is therefore increasingly recognized as a promising therapeutic strategy. In this regard, DEAD/H box RNA helicases are a very interesting group of proteins, with several family members regulating mRNA translation in cancer cells. In this review, we delineate the mechanisms by which DEAD/H box proteins modulate oncogenic translation and how inhibition of these RNA helicases can be exploited for anti-cancer therapeutics.
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