期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 48, 页码 15279-15283出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201707212
关键词
growth inhibition; HasA; heme proteins; protein structures; synthetic porphyrins
资金
- Ministry of Education, Culture, Sports, Science, and Technology (Japan) [26708018]
- JST CREST (Japan) [JPMJCR15P3]
- JSPS KAKENHI [JP15H05806]
- Grants-in-Aid for Scientific Research [26220807, 26708018, 17H01190, 16H01013, 15H05806] Funding Source: KAKEN
Iron(III)-5,15-diphenylporphyrin and several derivatives were accommodated by HasA, a heme acquisition protein secreted by Pseudomonas aeruginosa, despite possessing bulky substituents at the meso position of the porphyrin. Crystal structure analysis revealed that the two phenyl groups at the meso positions of porphyrin extend outside HasA. It was shown that the growth of P. aeruginosa was inhibited in the presence of HasA coordinating the synthetic porphyrins under iron-limiting conditions, and that the structure of the synthetic porphyrins greatly affects the inhibition efficiency.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据