期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 28, 期 6, 页码 399-415出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2017.02.005
关键词
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资金
- Intramural Research Program of the National Institutes of Health (NIH)/NIEHS
- NIH [R00ES022983]
- Albert McKern Scholar Award
Glucocorticoids are steroid hormones that regulate diverse cellular functions and are essential to facilitate normal physiology. However, stress-induced levels of glucocorticoids result in several pathologies including profound reproductive dysfunction. Compelling new evidence indicates that glucocorticoids are crucial to the establishment and maintenance of reproductive function. The fertility-promoting or - inhibiting activity of glucocorticoids depends on timing, dose, and glucocorticoid responsiveness within a given tissue, which is mediated by the glucocorticoid receptor (GR). The GR gene and protein are subject to cellular processing, contributing to signaling diversity and providing a mechanism by which both physiological and stress-induced levels of glucocorticoids function in a cell-specific manner. Understanding how glucocorticoids regulate fertility and infertility may lead to novel approaches to the regulation of reproductive function.
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