期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 28, 期 7, 页码 506-518出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2017.03.005
关键词
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资金
- US National Institutes of Health [R56DK046900-17A1]
- VA Merit Award [BX001728]
Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and plasma lipoproteins. The cellular and plasma concentrations of sphingo-lipids are altered in several metabolic disorders and may serve as prognostic and diagnostic markers. Here we discuss various sphingolipid transport mechanisms and highlight how changes in cellular and plasma sphingolipid levels contribute to cardiovascular disease, obesity, diabetes, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). Understanding of the mechanisms involved in intracellular transport, secretion, and extracellular transport may provide novel information that might be amenable to therapeutic targeting for the treatment of various metabolic disorders.
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