期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 28, 期 7, 页码 485-496出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2017.03.002
关键词
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资金
- Czech Science Foundation [13-25222J]
- National Sustainability Program I by Ministry of Education, Youth, and Sports of the Czech Republic [LO1503]
- US National Institutes of Health [R01 GM118122]
Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested in the diet. By modulating the activity of many proteins [e.g., liver X receptors (LXRs), oxysterol-binding proteins (OSBPs), some ATP-binding cassette (ABC) transporters], oxysterols can affect many cellular functions and influence various physiological processes (e.g., cholesterol metabolism, membrane fluidity regulation, intracellular signaling pathways). Therefore, the role of oxysterols is also important in pathological conditions (e.g., atherosclerosis, diabetes mellitus type 2, neurodegenerative disorders). Finally, current evidence suggests that oxysterols play a role in malignancies such as breast, prostate, colon, and bile duct cancer. This review summarizes the physiological importance of oxysterols in the human body with a special emphasis on their roles in various tumors.
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