期刊
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
卷 19, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s12968-017-0405-z
关键词
Whole-heart; Black-blood; Bright-blood; Late gadolinium enhancement (LGE); Coronary MR angiography
资金
- EPSRC [EP/N009258/1, EP/P001009/1, EP/P007619/1]
- MRC [MR/L009676/1]
- FONDECYT [1161051]
- Wellcome EPSRC Centre for Medical Engineering at King's College London [WT 203148/Z/16/Z]
- Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre
- King's College London
- King's College Hospital NHS Foundation Trust
- EPSRC [EP/N009258/1, EP/P001009/1, EP/P007619/1] Funding Source: UKRI
- MRC [MR/L009676/1] Funding Source: UKRI
- Academy of Medical Sciences (AMS) [AMS-NAF1-Yang] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/P007619/1, EP/N009258/1, EP/P001009/1] Funding Source: researchfish
- Medical Research Council [MR/L009676/1] Funding Source: researchfish
Background: Phase sensitive inversion recovery (PSIR) applied to late gadolinium enhancement (LGE) imaging is widely used in clinical practice. However, conventional 2D PSIR LGE sequences provide sub-optimal contrast between scar tissue and blood pool, rendering the detection of subendocardial infarcts and scar segmentation challenging. Furthermore, the acquisition of a low flip angle reference image doubles the acquisition time without providing any additional diagnostic information. The purpose of this study was to develop and test a novel 3D whole-heart PSIR-like framework, named BOOST, enabling simultaneous black-blood LGE assessment and bright-blood visualization of cardiac anatomy. Methods: The proposed approach alternates the acquisition of a 3D volume preceded by a T-2-prepared Inversion Recovery (T(2)Prep-IR) module (magnitude image) with the acquisition of a T-2-prepared 3D volume (reference image). The two volumes (T(2)Prep-IR BOOST and bright-blood T(2)Prep BOOST) are combined in a PSIR-like reconstruction to obtain a complementary 3D black-blood volume for LGE assessment (PSIR BOOST). The black-blood PSIR BOOST and the bright-blood T(2)Prep BOOST datasets were compared to conventional clinical sequences for scar detection and coronary CMR angiography (CMRA) in 18 patients with a spectrum of cardiovascular disease (CVD). Results: Datasets from 12 patients were quantitatively analysed. The black-blood PSIR BOOST dataset provided statistically improved contrast to noise ratio (CNR) between blood and scar when compared to a clinical 2D PSIR sequence (15.8 +/- 3.3 and 4.1 +/- 5.6, respectively). Overall agreement in LGE depiction was found between 3D black-blood PSIR BOOST and clinical 2D PSIR acquisitions, with 11/12 PSIR BOOST datasets considered diagnostic. The bright-blood T(2)Prep BOOST dataset provided high quality depiction of the proximal coronary segments, with improvement of visual score when compared to a clinical CMRA sequence. Acquisition time of BOOST (similar to 10 min), providing information on both LGE uptake and heart anatomy, was comparable to that of a clinical single CMRA sequence. Conclusions: The feasibility of BOOST for simultaneous black-blood LGE assessment and bright-blood coronary angiography was successfully tested in patients with cardiovascular disease. The framework enables free-breathing multi-contrast whole-heart acquisitions with 100% scan efficiency and predictable scan time. Complementary information on 3D LGE and heart anatomy are obtained reducing examination time.
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