期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 28, 期 9, 页码 669-683出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2017.06.001
关键词
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资金
- Danish Council for Independent Research \ Health Science
- Lundbeck Foundation
- Novo Nordisk Foundation
- Novo Nordisk Fonden [NNF14OC0012021, NNF12OC0001867] Funding Source: researchfish
- Villum Fonden [00007292] Funding Source: researchfish
The skin is the largest sensory organ of the human body. The skin not only prevents loss of water and other components of the body, but also is involved in regulation of body temperature and serves as an essential barrier, protecting mammals from both routine and extreme environments. Given the importance of the skin in temperature regulation, it is surprising that adaptive alterations in skin functions and morphology only vaguely have been associated with systemic physiological responses. Despite that impaired lipid metabolism in the skin often impairs the epidermal permeability barrier and insulation properties of the skin, its role in regulating systemic physiology and metabolism is yet to be recognized.
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