期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 28, 期 3, 页码 199-212出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2016.09.005
关键词
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资金
- European Union (EU)'s H2020 Project 'Propag-ageing' [634821]
- EU FP7 NU-AGE [266486]
- University of Bologna FARB linea 2 Project [RFB0120790]
- H2020 Societal Challenges Programme [634821] Funding Source: H2020 Societal Challenges Programme
'Inflammaging' refers to the chronic, low-grade inflammation that characterizes aging. Inflammaging is macrophage centered, involves several tissues and organs, including the gut microbiota, and is characterized by a complex balance between pro-and anti-inflammatory responses. Based on literature data, we argue that the major source of inflammatory stimuli is represented by endogenous/self, misplaced, or altered molecules resulting from damaged and/or dead cells and organelles (cell debris), recognized by receptors of the innate immune system. While their production is physiological and increases with age, their disposal by the proteasome via autophagy and/or mitophagy progressively declines. This 'autoreactive/autoimmune' process fuels the onset or progression of chronic diseases that can accelerate and propagate the aging process locally and systemically. Consequently, inflammaging can be considered a major target for antiaging strategies.
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