期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 28, 期 1, 页码 3-18出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2016.10.003
关键词
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资金
- Horizon 2020 Framework Program of European Union [634413]
- National Institute for Health Research (Academic Clinical Fellowship)
- Medical Research Council Metabolic Diseases Unit
- British Heart Foundation
- Biotechnology and Biological Sciences Research Council [BB/J009865/1] Funding Source: researchfish
- British Heart Foundation [RG/12/13/29853] Funding Source: researchfish
- Medical Research Council [G0400192, MC_UU_12012/5/B, G0802051, MC_UU_12012/2] Funding Source: researchfish
- National Institute for Health Research [ACF-2015-14-001] Funding Source: researchfish
- BBSRC [BB/J009865/1] Funding Source: UKRI
- MRC [MC_UU_12012/2, G0802051, G0400192] Funding Source: UKRI
Metabolic homeostasis emerges from the complex, multidirectional crosstalk between key metabolic tissues including adipose tissue, liver, and skeletal muscle. This crosstalk, traditionally mediated by hormones and metabolites, becomes dysregulated in human diseases such as obesity and diabetes. Extra cellular vesicles (EVs; including exosomes) are circulating, cell-derived nano particles containing proteins and nucleic acids that interact with and modify local and distant cellular targets. Accumulating evidence, reviewed herein, supports a role for extracellular vesicles in obesity-associated metabolic disturbance, particularly the local and systemic inflammation characteristic of adipose and hepatic stress. As the practical and conceptual challenges facing the field are tackled, this emerging and versatile mode of intercellular communication may afford valuable insights and therapeutic opportunities in combatting these major threats to modern human health.
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