期刊
TRENDS IN COGNITIVE SCIENCES
卷 21, 期 2, 页码 111-124出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2016.12.007
关键词
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资金
- Bernstein Computational Neuroscience Program of the German Federal Ministry of Education and Research [01GQ1001C]
- Deutsche Forschungsgemeinschaft (DFG), Neurocure [SFB 940, Exc 257, KF0247]
- German-Israeli Project Cooperation DIP [JA 945/3-1]
- European Regional Development Fund [10153458, 10153460]
- VENI grant from the Netherlands Organisation for Scientific Research (NWO) [451.13.023]
- DFG grant [SP 1510/2-1]
- NWO [823-02-010]
- European Union (Human Brain Project)
- European Union (ERC Grant) [339490]
- European Research Council (ERC) [339490] Funding Source: European Research Council (ERC)
Studies in humans and non-human primates have provided evidence for storage of working memory contents in multiple regions ranging from sensory to parietal and prefrontal cortex. We discuss potential explanations for these distributed representations: (i) features in sensory regions versus prefrontal cortex differ in the level of abstractness and generalizability; and (ii) features in prefrontal cortex reflect representations that are transformed for guidance of upcoming behavioral actions. We propose that the propensity to produce persistent activity is a general feature of cortical networks. Future studies may have to shift focus from asking where working memory can be observed in the brain to how a range of specialized brain areas together transform sensory information into a delayed behavioral response.
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