期刊
TRENDS IN COGNITIVE SCIENCES
卷 21, 期 11, 页码 878-892出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2017.08.006
关键词
-
资金
- Commissariat a l'Energie Atomique et aux Energies Alternatives (CEA)
- Institut National de la Sante et de la Recherche Medicale (INSERM), College de France
- Fondation pour la Recherche Medicale (FRM)
- Bettencourt-Schueller Foundation
- Canadian Institute for Advanced Research (CIFAR)
Schizophrenia is a severe and complex psychiatric disorder resulting in delusions, hallucinations, and cognitive impairments. Across a variety of paradigms, an elevated threshold for conscious perception has been repeatedly observed in persons with schizophrenia. Remarkably, even subtle measures of subliminal processing appear to be preserved. We argue here that the dissociation between impaired conscious access and intact unconscious processing may be due to a specific disruption of top-down attentional amplification. This proposal is compatible with the neurophysiological disturbances observed in schizophrenia, including dysconnectivity, abnormal neural oscillations, and glutamatergic and cholinergic dysregulation. Therefore, placing impaired conscious access as a central feature of schizophrenia can help researchers develop a coherent and parsimonious pathophysiological framework of the disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据