期刊
TRENDS IN CELL BIOLOGY
卷 27, 期 6, 页码 453-463出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2017.02.004
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资金
- Ecole Polytechnique Federale de Lausanne
- Swiss National Science Foundation [31003A-140780]
- AgingX program of the Swiss Initiative for Systems Biology [51RTP0-151019]
- NIH [R01AG043930]
- Swiss National Science Foundation (SNF) [31003A_140780] Funding Source: Swiss National Science Foundation (SNF)
Through epigenetic mechanisms cells integrate environmental stimuli to fine-tune gene expression levels. Mitochondrial function is essential to provide the intermediate metabolites necessary to generate and modify epigenetic marks in the nucleus, which in turn can regulate the expression of mitochondrial proteins. In this review we summarize the function of mitochondria in the regulation of epigenetic mechanisms as a new aspect of mitonuclear communication. We focus in particular on the most common epigenetic modifications histone acetylation and histone and DNA methylation. We also discuss the emerging field of mitochondrial DNA (mtDNA) methylation, whose physiological role remains unknown. Finally, we describe the essential role of some histone modifications in regulating the mitochondrial unfolded protein response (UPIRmt) and the mitochondrial stress-dependent lifespan extension.
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