期刊
TRENDS IN CELL BIOLOGY
卷 27, 期 4, 页码 241-254出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.10.005
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资金
- National Institutes of Health [R01-AI087644]
- National Science Foundation [1562905]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1562905] Funding Source: National Science Foundation
T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force. In recent years, it has become increasingly clear that synaptic forces influence information transfer both into and out of the lymphocyte. Here, we review our current understanding of synapse mechanics, focusing on its role as an avenue for intercellular communication.
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