期刊
TRENDS IN CELL BIOLOGY
卷 27, 期 11, 页码 797-809出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2017.08.009
关键词
-
类别
资金
- Wellcome Centre for Mitochondrial Research [203105]
- Newcastle University Centre for Ageing and Vitality (Biotechnology and Biological Sciences Research Council)
- Newcastle University Centre for Ageing and Vitality (Medical Research Council)
- UK National Institute for Health Research (NIHR) Biomedical Research Centre for Ageing and Age-related disease award
- FONDECYT [1150677]
- National Institutes of Health(NIH) [DK051526]
- NIH [GM119793]
- Wharton Fund
- Biotechnology and Biological Sciences Research Council [BB/M012093/1] Funding Source: researchfish
- Medical Research Council [G0700718B, G0700718, G0800674, 1594323, MC_G0802536, MR/L016354/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0514-10077, NF-SI-0510-10187] Funding Source: researchfish
- NIHR Newcastle Biomedical Research Centre [BH111030] Funding Source: researchfish
- BBSRC [BB/M012093/1] Funding Source: UKRI
- MRC [G0800674, MR/L016354/1, G0700718, MC_G0802536] Funding Source: UKRI
Insight into the regulation of complex physiological systems emerges from understanding how biological units communicate with each other. Recent findings show that mitochondria communicate at a distance with each other via nanotunnels, thin double-membrane protrusions that connect the matrices of non-adjacent mitochondria. Emerging evidence suggest that mitochondrial nanotunnels are generated by immobilized mitochondria and transport proteins. This review integrates data from the evolutionarily conserved structure and function of intercellular projections in bacteria with recent developments in mitochondrial imaging that permit nanotunnel visualization in eukaryotes. Cell type-specificity, timescales, and the selective size-based diffusion of biomolecules along nanotunnels are also discussed. The joining of individual mitochondria into dynamic networks of communicating organelles via nanotunnels and other mechanisms has major implications for organelle and cellular behaviors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据