期刊
TRENDS IN CELL BIOLOGY
卷 27, 期 12, 页码 880-884出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2017.09.001
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资金
- Spanish Instituto de Salud Carlos III (FIS) [PI16/01485]
- Plan Nacional de I+D+I
- EU Fondos Feder
- Instituto de Salud Carlos III [PI16/01318]
- Plan de Ciencia, Tecnologia e Innovacion del Principado de Asturias [GRUPIN-14-030]
- Ligue contre le Cancer Comite de Charente-Maritime (equipe labelisee)
- Agence National de la Recherche (ANR)-Projets Blancs
- ANR under frame of E-Rare-2
- ERA-Net for Research on Rare Diseases
- Association pour la Recherche sur le Cancer (ARC)
- Canceropole Ile-de-France
- Institut National du Cancer (INCa)
- Inserm (HTE)
- Institut Universitaire de France
- Fondation pour la Recherche Medicale (FRM)
- European Commission (ArtForce)
- European ResearchCouncil(ERC)
- Fondation Carrefour
- LeDucq Foundation
- LabEx Immuno-Oncology
- RHU Torino Lumiere
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- Paris Alliance of Cancer Research Institutes (PACRI)
A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.
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