PEGylated Carbon Nano-onions Composite as a Carrier of Polyphenolic Compounds: A Promising System for Medical Applications and Biological Sensors

Natural polyphenols and their composites display a wide range of biological activities. Therefore, they are extensively studied in terms of biological and medical applications. An example is 1,2,3,4,6-penta-beta-O-galloyl-D-glucopyranose (beta-PGG), a glycoside that is known to exert numerous protective effects on mammalian cells. Moreover, it is a strong antibacterial compound. Herein, we analysed the potential application of a composite composed of carbon nano-onions (CNOs) and polyethylene glycole (PEG 400) as a carrier of beta-PGG. Bioaccessibility of the glycoside and gallic acid (GA) was assessed with surface plasmon resonance spectroscopy (SPR) to study the interaction of beta-PGG and GA with a synthetic triple helical collagen-like peptide.