期刊
TRENDS IN CARDIOVASCULAR MEDICINE
卷 27, 期 8, 页码 521-531出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2017.06.013
关键词
Tissue engineering; Tissue-engineered vascular graft; Congenital cardiac disease; Surgery; Fontan; Bone marrow-derived mononuclear cells
资金
- National Center For Advancing Translational Sciences [TL1TR001069]
- Gunze Ltd.
Congenital heart disease is a leading cause of death in the newborn period, and man-made grafts currently used for reconstruction are associated with multiple complications. Tissue engineering can provide an alternative source of vascular tissue in congenital cardiac surgery. Clinical trials have been successful overall, but the most frequent complication is graft stenosis. Recent studies in animal models have indicated the important role of the recipient's immune response in neotissue formation, and that modulating the immune response can reduce the incidence of stenosis.
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