期刊
TRENDS IN BIOTECHNOLOGY
卷 35, 期 8, 页码 728-742出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2017.03.013
关键词
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资金
- German Research Foundation (DFG) [UR 70/10-01, UR 70/12-01]
- ETH Zurich Foundation
- European Research Council (ERC), Consolidator Grant 'HybCell' [681587]
- European Research Council (ERC) [681587] Funding Source: European Research Council (ERC)
Multiplexed point-of-care testing (xPOCT), which is simultaneous on-site detection of different analytes from a single specimen, has recently gained increasing importance for clinical diagnostics, with emerging applications in resource-limited settings (such as in the developing world, in doctors' offices, or directly at home). Nevertheless, only single-analyte approaches are typically considered as the major paradigm in many reviews of point-of-care testing. Here, we comprehensively review the present diagnostic systems and techniques for xPOCT applications. Different multiplexing technologies (e.g., bead-or array-based systems) are considered along with their detection methods (e.g., electrochemical or optical). We also address the unmet needs and challenges of xPOCT. Finally, we critically summarize the in-field applicability and the future perspectives of the presented approaches.
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