期刊
TRENDS IN BIOTECHNOLOGY
卷 35, 期 2, 页码 172-183出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2016.08.001
关键词
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资金
- National Science Foundation (CAREER award) [CBET-1351909]
- National Institute of Biomedical Imaging and Bioengineering [7R03EB019184-03]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1557348] Funding Source: National Science Foundation
Drug-induced liver injury (DILI) remains a leading cause of drug withdrawal from human clinical trials or the marketplace. Owing to species-specific differences in liver pathways, predicting human-relevant DILI using in vitro human liver models is crucial. Microfabrication tools allow precise control over the cellular microenvironment towards stabilizing liver functions for weeks. These tools are used to engineer human liver models with different complexities and throughput using cell lines, primary cells, and stem cell-derived hepatocytes. Including multiple human liver cell types can mimic cell-cell interactions in specific types of DILL Finally, organ-on-a-chip models demonstrate how drug metabolism in the liver affects multi-organ toxicities. In this review we survey engineered human liver platforms within the needs of different phases of drug development.
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