期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 42, 期 4, 页码 255-273出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2016.11.003
关键词
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资金
- Argentinean Agency for Promotion of Science and Technology [PICT V 2014-367, PICT 2012-2440, PICT 2012-646, PICT 2013-0919, PICT 2014-1478]
- CONICET [PIP 2013-0919]
- University of Buenos Aires
- Sales, Bunge & Born Foundation
- Kenneth Rainin Foundation
- Ferioli family
- Ostry family
- Caraballo family
The vast range and complexity of glycan structures and their dynamic variations in health and disease have presented formidable challenges toward understanding the biological significance of these molecules. Despite these limitations, compelling evidence highlights a major role for galectins, a family of soluble glycan-binding proteins, as endogenous decoders that translate glycan-containing information into a broad spectrum of cellular responses by modulating receptor clustering, reorganization, endocytosis, and signaling. Here, we underscore pioneer findings and recent advances in understanding the biology of galectin-glycan interactions in myeloid, lymphoid, and endothelial compartments, highlighting important pathways by which these multivalent complexes control immune and vascular programs. Implementation of novel glycoanalytical approaches, as well as the use of genetically engineered cell and organism models, have allowed glycans and galectins to be explored across a range of cellular processes.
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