期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 42, 期 9, 页码 726-737出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2017.01.005
关键词
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资金
- Ministry of Economy and Competitiveness (MINECO) [BI02013-41019-P, BI02016-76063-R]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR) [2014SGR-132]
- Marata de TV3 foundation [TV32013-132031, TV32013-3930]
- Centro de Investigacion Biomedica en Red (GIBER) de Bioingenieria, Biomateriales y Nanomedicina
- Fondo de Investigaciones Sanitarias (FIS) [PI15/00272]
- Cluster of Excellence 'Rebirth' and German Research group [2180]
- Asociacion Espanola Contra el Cancer (AECC)
- Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (DOC-INIA, MINECO)
- European Social Fund and the Centres de Recerca de Catalunya (CERCA) Programme (Generalitat de Catalunya)
Bacterial inclusion bodies (lBs) are functional, non-toxic amyloids occurring in recombinant bacteria showing analogies with secretory granules of the mammalian endocrine system. The scientific interest in these mesoscale protein aggregates has been historically masked by their status as a hurdle in recombinant protein production. However, progressive understanding of how the cell handles the quality of recombinant polypeptides and the main features of their intriguing molecular organization has stimulated the interest in inclusion bodies and spurred their use in diverse technological fields. The engineering and tailoring of !Bs as functional protein particles for materials science and biomedicine is a good example of how formerly undesired bacterial byproducts can be rediscovered as promising functional materials for a broad spectrum of applications.
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