期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 42, 期 7, 页码 499-501出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2017.05.008
关键词
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资金
- Melanoma Research Alliance, NIH [R01GM101171, 2R01HL114858, R21AG053561]
- DoD [OC140123]
- Glenn Foundation for Medical Research
- Love Your Melon/St. Baldrick's Foundation
- Harrington Discovery Institute
- University of Michigan Cancer Research Committee
Despite the fact that SIRT4 regulates important biological processes, its primary enzymatic activity has remained ambiguous. A recent study by Anderson, Huynh et al. has uncovered deacylase activities of SIRT4 towards newly described lysine modifications derived from reactive acyl-CoAs generated in leucine catabolism.
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