4.6 Editorial Material

For Certain, SIRT4 Activities!

期刊

TRENDS IN BIOCHEMICAL SCIENCES
卷 42, 期 7, 页码 499-501

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ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2017.05.008

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资金

  1. Melanoma Research Alliance, NIH [R01GM101171, 2R01HL114858, R21AG053561]
  2. DoD [OC140123]
  3. Glenn Foundation for Medical Research
  4. Love Your Melon/St. Baldrick's Foundation
  5. Harrington Discovery Institute
  6. University of Michigan Cancer Research Committee

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Despite the fact that SIRT4 regulates important biological processes, its primary enzymatic activity has remained ambiguous. A recent study by Anderson, Huynh et al. has uncovered deacylase activities of SIRT4 towards newly described lysine modifications derived from reactive acyl-CoAs generated in leucine catabolism.

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