期刊
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
卷 12, 期 -, 页码 179-184出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bcab.2017.10.003
关键词
Leishmaniasis; Essential oil; Bactericidal effect; Antioxidant effect; Antileishmanial effect
资金
- National Center for Scientific and Technical Research (NCSTR) from Morocco [376UM5]
This study aimed to reveal the chemical composition of Lavandula stoechas L. (L. stoechas) essential oils and to evaluate their antileishmanial, antibacterial and antioxidant properties. The essential oil was extracted by hydrodistillation using Clevenger apparatus. The chemical composition of L. stoechas essential oil was determined using GC-MS analysis. The antibacterial activity was tested against pathogenic strains using the diffusion method, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by microtitration assay. The antioxidant activity was estimated by DPPH free radical scavenging ability and ferricreducing power. The antiparasitic activity was tested against Leishmania major, Leishmania tropica and Leishmania infantum using MTT (3-(4.5-dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide) assay. The major components of L. stoechas essential oils are represented by fenchone (31.81%), camphor (29.60%), terpineol (13.14%), menthone (8.96%) and eucalyptol (5.88%). The oil has revealed an important antioxidant capacity compared with ascorbic acid and Trolox. The highest inhibition was obtained against Listeria monocytogenes and Staphylococcus aureus MBLA by a diameter inhibition of 23 +/- 0.85 and 21 +/- 0.25 mm respectively. The lowest MIC and MBC values were obtained against L. monocytogenes (MIC = MBC = 0.25% (v/v)). The essential oil was most active against L. major with an IC50 value of 0.9 +/- 0.45% (v/v). From these results, we conclude that L. stoechas essential oils could have potential applications in the food and pharmaceutical industries.
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