期刊
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
卷 354, 期 4, 页码 335-338出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjms.2017.02.008
关键词
Secondary hyperparathyroidism; Heart failure; Hypocalcemia; Hypomagnesemia
Secondary hyperparathyroidism (SHPT) is a well-known pathophysiologic feature of chronic renal failure. In recent years, SHPT has become recognized as a complication of the aldosteronism associated with congestive heart failure and where excretory Ca2+ and Mg2+ wasting results in plasma-ionized hypocalcemia and hypomagnesemia. Elevations in plasma parathyroid hormone have adverse systemic consequences, including intracellular Ca2+ overloading of myocytes and vascular smooth muscle with the induction of oxidative stress. Herein, we briefly review the presence and adverse outcomes of SHPT in persons with heart failure.
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