期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1863, 期 10, 页码 2564-2573出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2017.01.013
关键词
Sepsis; Trauma; Inflammation; Infection; PAMP; DAMP
资金
- National Institute of General Medical Sciences (NIGMS), U.S.P.H.S [R01 GM-040586, R01 GM-104481, R01 GM-113945, R01 GM-097531, R01 GM-105893, P50 GM-111152]
- NIGMS [T32 GM-08721]
Early host recognition of microbial invasion or damaged host tissues provides an effective warning system by which protective immune and inflammatory processes are initiated. Host tissues responsible for continuous sampling of their local environment employ cell surface and cytosolic pattern recognition receptors (PRRs) that provide redundant and overlapping identification of both microbial and host alarmins. Microbial products containing pathogen-associated molecular patterns (PAMPs), as well as damage-associated molecular patterns (DAMPS) serve as principle ligands for recognition by these PRRs. It is this interaction which plays both an essential survival role in response to infection and injury, as well as the pathologic role in tissue and organ injury associated with severe sepsis and trauma. Elucidating the interaction between ligands and their respective PRRs can provide both a better understanding of the host response, as well as a rational basis for therapeutic intervention. This article is part of a Special Issue entitled: Immune and Metabolic Alterations in Trauma and Sepsis edited by Dr. Raghavan Raju. (C) 2017 Elsevier B.V. All rights reserved.
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