期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 25, 期 23, 页码 6224-6228出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2017.07.005
关键词
Flow synthesis; Methyl azide
资金
- MEXT [26220804, 25220913, 26288049, 15H05849]
- Grants-in-Aid for Scientific Research [26288049, 26220804, 15H05849] Funding Source: KAKEN
Generation and reactions of methyl azide (MeN3) were successfully performed by using a flow reactor system, demonstrating that the flow method serves as a safe method for handling hazardous explosive methyl azide. The reaction of NaN3 and Me2SO4 in a flow reactor gave a MeN3 solution, which was used for Huisgen reaction with benzoyl cyanide in a flow reactor after minimal washing. The resulting 1-methyl-5-benzoyltetrazole serves as a key intermediate of picarbutrazox (IX), a new potent pesticide. (C) 2017 Published by Elsevier Ltd.
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