期刊
TRANSPLANT INFECTIOUS DISEASE
卷 19, 期 4, 页码 -出版社
WILEY
DOI: 10.1111/tid.12702
关键词
complications; dermatologic complication; immunosuppressive regimens; infection and infectious agents; infectious; leflunomide; minimization/withdrawal; trichodysplasia spinulosa; trichodysplasia spinulosa-associated polyomavirus; viral
Trichodysplasia spinulosa (TS) is a rare dermatologic complication associated with the immunosuppressive therapy used in solid organ transplantation. The distinctive clinical manifestation of this condition is spiny follicular papules on the face, ears, extremities, and trunk. Histopathologically, abnormally maturing hair follicles with hyperkeratotic material are noted. The condition is produced by the trichodysplasia spinulosa-associated polyomavirus. Treatment of this condition in the past has entailed a reduction in immunosuppression, topical agents such as cidofovir or retinoids, or oral valganciclovir. Herein, we report a case of generalized TS treated successfully with leflunomide.
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