期刊
TRANSLATIONAL RESEARCH
卷 184, 期 -, 页码 101-107出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2017.02.004
关键词
-
资金
- NIH [DK093954, F32 DK104501]
- VA Merit Award [I01 BX001733]
Despite accumulating evidence demonstrating strong epidemiologic and mechanistic associations between cigarette smoking, hyperglycemia, and the development of type 2 diabetes, tobacco abuse has not been uniformly recognized as a modifiable risk factor in diabetes prevention or screening strategies. In this review, we highlight population-based studies that have linked cigarette smoking with an increased risk of type 2 diabetes and summarize clinical and preclinical studies offering insight into mechanisms through which cigarette smoking and nicotine exposure impact body composition, insulin sensitivity, and pancreatic 13 cell function. Key questions for future studies are identified and strategies for smoking cessation as a means to decrease diabetes risk are discussed.
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