期刊
ANNALS OF BIOMEDICAL ENGINEERING
卷 45, 期 12, 页码 2888-2898出版社
SPRINGER
DOI: 10.1007/s10439-017-1925-2
关键词
Magnetics; Microfluidic; Malaria; Apheresis; Separation; Treatment; Modeling
资金
- National Institutes of Health [R01 HL089456]
This study describes a non-dilutive high-gradient magnetic separation (HGMS) device intended to continuously remove malaria-infected red blood cells (iRBCs) from the circulation. A mesoscale prototype device with disposable photo-etched ferromagnetic grid and reusable permanent magnet was designed with a computationally-optimized magnetic force. The prototype device was evaluated in vitro using a non-pathogenic analog for malaria-infected blood, comprised of 24% healthy RBCs, 6% human methemoglobin RBCs (metRBCs), and 70% phosphate buffer solution (PBS). The device provided a 27.0 +/- 2.2% reduction of metRBCs in a single pass at a flow rate of 77 mu L min(-1). This represents a clearance rate over 380 times greater throughput than microfluidic devices reported previously. These positive results encourage development of a clinical scale system that would economize time and donor blood for treating severe malaria.
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