期刊
TRANSLATIONAL RESEARCH
卷 185, 期 -, 页码 24-33出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2017.04.001
关键词
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资金
- NIRS
- Center of Innovation Program (COI stream from JST)
- Kakenhi [23700589, 24300167, 17H00860]
- Heavy-Ions at NIRS-HIMAC project
- Grants-in-Aid for Scientific Research [17H03068, 23700589, 17H00860] Funding Source: KAKEN
The combination of radiotherapy with chemotherapy is one of the most promising strategies for cancer treatment. Here, a novel combination strategy utilizing carbon ion irradiation as a high-linear energy transfer (LET) radiotherapy and a thermo-triggered nanodevice is proposed, and drug accumulation in the tumor and treatment effects are evaluated using magnetic resonance imaging relaxometry and immunohistology (Ki-67, n = 15). The thermo-triggered liposomal anticancer nanodevice was administered into colon-26 tumor-grafted mice, and drug accumulation and efficacy was compared for 6 groups (n = 32) that received or did not receive the radiotherapy and thermo trigger. In vivo quantitative R1 maps visually demonstrated that the multimodal thermosensitive polymer-modified liposomes (MTPLs) can accumulate in the tumor tissue regardless of whether the region was irradiated by carbon ions or not. The tumor volume after combination treatment with carbon ion irradiation and MTPLs with thermo-triggering was significantly smaller than all the control groups at 8 days after treatment. The proposed strategy of combining high-LET irradiation and the nanodevice provides an effective approach for minimally invasive cancer treatment.
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