期刊
CELL BIOCHEMISTRY AND BIOPHYSICS
卷 75, 期 3-4, 页码 369-385出版社
HUMANA PRESS INC
DOI: 10.1007/s12013-017-0792-7
关键词
EPR; Oximetry; Lipid spin label; Membrane domains; Cholesterol
资金
- National Institutes of Health, USA [EY015526, EB001980, EY001931]
- Ministry of Science and Higher Education, Poland
Lipid composition determines membrane properties, and cholesterol plays a major role in this determination as it regulates membrane fluidity and permeability, as well as induces the formation of coexisting phases and domains in the membrane. Biological membranes display a very diverse lipid composition, the lateral organization of which plays a crucial role in regulating a variety of membrane functions. We hypothesize that, during biological evolution, membranes with a particular cholesterol content were selected to perform certain functions in the cells of eukaryotic organisms. In this review, we discuss the major membrane properties induced by cholesterol, and their relationship to certain membrane functions.
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