期刊
TRANSFUSION MEDICINE REVIEWS
卷 31, 期 1, 页码 36-44出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.tmrv.2016.07.003
关键词
Regulatory T cell; Immunotherapy; Cell processing; T-cell differentiation; Antigen specificity; Lineage stability
类别
资金
- National Institutes of Health [K08 DK104021A]
The balanced differentiation of naive CD4(+) T cells into either pro- or anti-inflammatory fates is a central regulator of immune homeostasis, dysregulation of which can lead to inflammatory disease or cancer. Accordingly, the development of diagnostics and therapeutics to measure and modulate this balance is of great interest. In this review, we focus on the predominant anti-inflammatory subset, regulatory T cells, discussing key concepts including development, function, antigen specificity, and lineage stability. In particular, we highlight how these notions are shaping the evolution of therapeutics, especially in the context of the transfusion medicine specialist, and identify several key areas that urgently need to be addressed. (C) 2016 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据