期刊
AIDS AND BEHAVIOR
卷 21, 期 12, 页码 3336-3345出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10461-017-1969-1
关键词
Acceptability; Gel; PrEP; Microbicide; Rectal
资金
- National Institute of Allergy and Infectious Diseases component of the U.S. National Institutes of Health [UM1AI068633, UM1AI068615, UM1AI106707]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development component of the U.S. National Institutes of Health
- National Institute of Mental Health component of the U.S. National Institutes of Health
- NIH Center grant [P30 MH43520]
- National Library of Medicine [R01-LM012355-01A1, T15-LM007079]
- National Institute of Mental Health [P60-MD006902]
Oral pre-exposure prophylaxis (PrEP) can prevent HIV transmission. Yet, some may prefer not to take systemic daily medication. MTN-017 was a 3-period, phase 2 safety and acceptability study of microbicide gel applied rectally either daily or before and after receptive anal intercourse (RAI), compared to daily oral tablet. At baseline, cisgender men and transgender women who reported RAI (N = 187) rated the daily oral regimen higher in overall liking, ease of use, and likelihood of future use than the gel regimens. After trying all three, 28% liked daily oral the least. Gel did not affect sexual enjoyment (88%) or improved it (7-8%). Most partners had no reaction to gel use. Ease of gel use improved significantly between the first and the last few times of daily use. A rectal gel used before and after RAI may constitute an attractive alternative to daily tablet. Experience with product use may increase acceptability.
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