期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 50, 页码 15959-15963出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201708635
关键词
cell adhesion; cell release; dynamic biointerfaces; epitopes; molecular imprinting
资金
- Marie Sklodowska-Curie Actions (H2020-MSCA-IF-EF) [658953]
- National Natural Science Foundation of China [21574091]
- Natural Science Foundation of Jiangsu Province [BK20160056]
- Marie Curie Actions (MSCA) [658953] Funding Source: Marie Curie Actions (MSCA)
In this study, an epitope-imprinting strategy was employed for the dynamic display of bioactive ligands on a material interface. An imprinted surface was initially designed to exhibit specific affinity towards a short peptide (i.e., the epitope). This surface was subsequently used to anchor an epitope-tagged cell-adhesive peptide ligand (RGD: Arg-Gly-Asp). Owing to reversible epitope-binding affinity, ligand presentation and thereby cell adhesion could be controlled. As compared to current strategies for the fabrication of dynamic biointerfaces, for example, through reversible covalent or host-guest interactions, such a molecularly tunable dynamic system based on a surface-imprinting process may unlock new applications in insitu cell biology, diagnostics, and regenerative medicine.
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