期刊
CLINICAL INFECTIOUS DISEASES
卷 65, 期 12, 页码 2137-2143出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cix675
关键词
Sepsis; nephrotoxicity; vancomycin; piperacillin/tazobactam
资金
- Allergan
Early administration of appropriate empiric antibiotics is essential for achieving the best possible outcomes in sepsis. Yet the choice of antibiotic therapy has become more challenging due to recent reports of nephrotoxicity with the combination of vancomycin and piperacillin/tazobactam, the workhorse regimen at many institutions. In this article we assess the evidence for nephrotoxicity and its possible mechanisms, provide recommendations for risk mitigation, address the advantages and disadvantages of alternative antibiotic choices, and suggest areas for future research.
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