期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 81, 期 11, 页码 2212-2215出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2017.1374830
关键词
autophagy; phosphatidylinositide 3-kinase; Nrf2; Keap1; benzyl isothiocyanate
类别
资金
- MEXT KAKENHI [25292073, 16K14928, 17H03818]
- Grants-in-Aid for Scientific Research [17K17923, 17H03818, 16K14928] Funding Source: KAKEN
The regulating role of phosphatidylinositide 3-kinase (PI3K) in benzyl isothiocyanate (BITC)-induced Nrf2 activation, contributing to the inducible expression of cytoprotective genes, was investigated. BITC significantly enhanced the accumulation of Nrf2 as well as autophagic molecules in human colorectal cancer HCT-116 cells. Experiments using a PI3K-specific inhibitor suggested that PI3K plays the key role in the non-canonical Nrf2 activation by BITC.
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