期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 65, 页码 16442-16446出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201703598
关键词
apoptosis; dna damage; photodynamic therapy; platinum
资金
- 973 program [2014CB845604, 2015CB856301]
- National Science Foundation of China [21231007, 2132810, 21572282]
- Guangdong government [207999, 2015A030306023]
- Ministry of Education of China [IRT17R111]
- US National Science Foundation [CHE-1213673]
Herein, two photosensitive platinum(II)-based tripods were designed and synthesized. Notably, complex1 ({[Pt(dien)](3)L}(NO3)(6), L=tri(4-pyridylphenyl)amine and dien=diethylenetriamine), which mainly accumulated in the cell nucleus, exhibited very low cytotoxicity in the absence of light irradiation, but displayed a remarkable increase in cytotoxicity upon visible light irradiation. Mechanistic investigations revealed that the tripod interacted with DNA in the nucleus, induced ROS generation upon light irradiation, and consequently elicited rapid DNA damage response; thereby triggering cancer cell apoptosis.
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