期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 94, 期 -, 页码 95-105出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2017.07.003
关键词
17 beta-estradiol; Aptasensor; Nanosensor; Bioaffinity sensors; Optical; Electrochemical assays
One of the most important endogenous estrogens is 17 beta-estradiol, which disturbed the endocrine system, and causing adverse effects on the growth, reproduction and development of the body. It is necessary to develop a convenient and rapid analytical method to detect estradiol with high sensitivity and selectivity. For determination of 17 beta-estradiol, methods such as high performance liquid chroma-tography/mass spectrometry and gas chromatography/mass spectrometry were used. However, these methods often need expensive instruments, complex pretreatment, large volumes of harmful solvents and professional operation. Aptamers have been used as a new biosensor platform for detection of 17 beta-estradiol in different samples. This article provides an overview of the applications of aptasensors in analysis and monitoring of 17 beta-estradiol. After a brief description of the steroids, recent advances and applications of aptamer-based biosensors are presented. We have paid attention to the potential role of bioaffinity systems in the detection and quantitative determination of 17 beta-estradiol. (C) 2017 Elsevier B.V. All rights reserved.
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