期刊
ACS APPLIED MATERIALS & INTERFACES
卷 9, 期 49, 页码 42589-42600出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b14267
关键词
p34hb; grapheni oxide; electrospinning; scaffold; bone tissue engineering; cell homing
资金
- National Natural Science Foundation of China [81671031, 81470721]
- Sichuan Province Youth Science and Technology Innovation Team [2014TD0001]
Bone tissue engineering emerges as an advantageous technique to achieve tissue regeneration. Its scaffolds must present excellent biomechanical properties, where bare polymers poorly perform. Development of new biomaterials with high osteogenic capacity is urgently pursued. In this study, an electrospun poly(3hydroxybutyrate-co-4-hydroxybutyrate)/grapheneoxide (P34HB/GO) nanofibrous scaffold is successfully fabricated and characterized. The effects of GO amount on scaffold morphology, biomechanical properties, and cellular behaviors are investigated. GO reduces the fiber diameter and enhances porosity, hydrophilicity, mechanical properties, cellular performance, and osteogenic differentiation of scaffolds. P34HB/GO triumphs over P34HB in in vivo bone regeneration in critical-sized calvarial defect of rats. We believe that this study is the first to evaluate the capability of in vivo bone repair of electrospun P34HB/GO scaffold. With facile fabrication process, favorable porous structures, properties, and fast osteogenic capability, P34HB/GO scaffold holds practical potentials for bone tissue engineering application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据