期刊
TOXICON
卷 137, 期 -, 页码 168-172出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2017.08.002
关键词
Antiparasitic agents; Molecular docking; Wasp venom; Mastoparan
资金
- Brazilian Research Agency CNPq
- FUNCAP
- CNPq [151182/2013-2, 447592/2014-9]
Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.
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