期刊
TOXICOLOGY LETTERS
卷 280, 期 -, 页码 1-9出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2017.07.898
关键词
Noise; Small intestine; Inflammation; Inflammatory bowel diseases (IBD)
类别
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [11220150100333CO]
- Universidad de Buenos Aires [20020150100205BA]
The influence of noise on the presentation and progression of inflammatory bowel diseases has been poorly analyzed. We designed this study to investigate immediate and late effects of acoustic stress (AS) on small intestine. To this aim, CBA/J, BALB/c and DBA/2 mice were divided into AS and control groups. AS mice were exposed to noise (300 Hz-70 dB) during 24hs and randomized into: A) Acute effects group: mice were killed after AS; L) Late effects group: mice were killed 3 weeks after AS and O) Over-exposed effects group: mice were submitted to AS once a week during a month and killed. Small intestine sections were histologically examined. The expression of cytokines (IL-17, IL-22, TNF-alpha, INF-gamma and TGF-beta), CCL-25 and Ki67 was studied by immunohistochemistry and immunofluorescence techniques. A group displayed short and fragmented villi, diminished number of lamina propria cells, leucocyte infiltration, higher number of goblet cells and predominance of IL-17 expression. L group showed epithelial proliferative foci (CCL25+Ki67+) and increased TNF alpha/TGF-beta expression. Tissue damage was aggravated in O group. In conclusion, AS is able to trigger a severe intestinal inflammatory process in healthy mice, which spontaneously amplifies and perpetuates. Noise might be harmful to humans by aggravating inflammatory bowel diseases.
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