期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 25, 期 24, 页码 6718-6723出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2017.11.019
关键词
Purine; Organoselenium compounds; Antioxidant; Acetylcholinesterase; Memory
资金
- CNPq [408874/2016-3, 400150/2014-0, 447595/2014-8]
- FAPERGS [PRONEM 16/2551-0000240-1, PRONUPEQ 16/2551-0000526-5]
- FINEP
- CAPES
We describe here a simple method for the synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities, and memory improvement effect. This class of compounds was synthesized in good yields by a reaction of 6-chloropurine with diaryl diselenides using NaBH4 as reducing agent and PEG-400 as solvent. Furthermore, the synthesized compounds were evaluated for their in vitro antioxidant and acetylcholinesterase (AChE) inhibitor activities. The best AChE inhibitor was assessed on the in vivo memory improvement. Our results demonstrated that the 6-((4-chlorophenyl) selanyl)-9H-purine and 6-(p-tolylselanyl)-9H-purine presented in vitro antioxidant effect. In addition, 6-((4-fluorophenyl)selanyl)-9H-purine inhibited the AChE activity and improved memory, being a promising therapeutic agent for the treatment of Alzheimer's disease. (C) 2017 Elsevier Ltd. All rights reserved.
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