期刊
CARBOHYDRATE POLYMERS
卷 178, 期 -, 页码 190-199出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.09.047
关键词
Chitosan; Hybrid; Bioscaffold; Bone regeneration; Sol-gel; Cytotoxicity
资金
- Center of Excellence for Innovation in Chemistry(PERCH-CIC), Office of the Higher Education Commission, Ministry of Education
Biohybrid chitosan-silica scaffolds were synthesized through the sol-gel and the freeze drying processes. Hydrolysis and condensation of chitosan with tetraethylorthosilicate (TEOS) in the presence of 3-isocyanatopropyl triethoxysilane (ICPTES) were successfully carried out. Results obtained from FTIR, swelling test and pyrolysis confirmed that the hybrid scaffolds containing covalent coupling between the organic and inorganic networks were formed with high crosslink density of Si-O-Si bridging and could be classified as the class II material. The hybridization also resulted in improvements on mechanical strength and stability comparing to the pure chitosan. In vitro investigations on the guided bone regeneration and the cytotoxicity were also performed. SEM-EDS was used to examine the proliferation of calcium phosphate mineral at the scaffold surface after an immersion in simulated body fluid. The results revealed that the hybrid scaffolds exhibited a rapid induction of calcium phosphate mineral without cytotoxicity effect, reflecting an excellent in vitro bone bioactivity which was superior to the pure chitosan scaffold.
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