期刊
BIOSENSORS & BIOELECTRONICS
卷 98, 期 -, 页码 478-485出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2017.06.061
关键词
Point-of-care testing; Paper microfluidics; Biosensor; Writing; Wax pen; Ink pen
类别
资金
- National Instrumentation Program of China [2013YQ190467]
- International Science and Technology Cooperation and Exchange Program of Shaanxi Province of China [2016KW-064]
- Fundamental Research Funds for the Central Universities of China [0109-1191320016]
- China Postdoctoral Science Foundation [2016M5927736]
Paper-based microfluidic biosensors have recently attracted increasing attentions in point-of-care testing (POCT) territories benefiting from their affordable, accessible and eco-friendly features, where technologies for fabricating such biosensors are preferred to be equipment free, easy-to-operate and capable of rapid prototyping. In this work, we developed a pen-on-paper (PoP) strategy based on two custom-made pens, i.e., a wax pen and a conductive-ink pen, to fully write paper-based microfluidic biosensors through directly writing both microfluidic channels and electrodes. Particularly, the proposed wax pen is competent to realize one-step fabrication of wax channels on paper, as the melted wax penetrates into paper during writing process without any post-treatments. The practical applications of the fabricated paper-based microfluidic biosensors are demonstrated by both colorimetric detection of Salmonella typhimurium DNA with detection limit of 1 nM and electrochemical measurement of glucose with detection limit of 1 mM. The developed PoP strategy for making microfluidic biosensors on paper characterized by true simplicity, prominent portability and excellent capability for rapid prototyping shows promising prospect in POCT applications.
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